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I spent a little time upping the rate until I hit the max of 15 mg/hr. That d*** heart rate still wouldn't go down. I got new orders for a Amiodarone drip, but I only had one line. She was an extremely hard stick and the whole ER was taking turns.
The objective of this study was to assess the impact of IV and PO amiodarone overlap on short-term tachyarrhythmia recurrence and adverse hemodynamic outcomes in the intensive care unit. Intravenous amiodarone is a recognised treatment alternative for the conversion of atrial fibrillation to sinus rhythm.1–3 Consensus regarding dosage and duration of treatment has not been reached.4,5 Our coronary care unit routinely uses intravenous amiodarone for conversion of supraventricular arrhythmia in various clinical settings. Amiodarone (Cordarone, Pacerone) Clinical Guideline NOVEMBER 2013 ©2013 INTERMOUNTAIN HEALTHCARE. Cardiovascular Clinical Program. 11/4/2013. Awaiting final Pharmacy & Therapeutics approval. page 1 of 2 (Patient & Provider Publications 801-442-2963) Table 1 - Intravenous Amiodarone SITUATION IV PUSH or BOLUS MAINTENANCE INFUSION* NOTES Cardiac Anyway, the admitting doc ordered a cardizem titration drip.
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Maximum daily dose: 2.1 g/day.
Amiodarone is a class III antiarrhythmic agent and is used for the treatment of various types of tachyarrhythmias. Because of the toxicity and serious side-effects of amiodarone, use it cautiously and do not exceed the cumulative total of 2.2 grams in 24 hours. Amiodarone is metabolized to desethylamiodarone by the cytochrome P450 (CYP450) enzyme group, specifically cytochrome P450 3A4 (CYP3A4) and CYP2C8.
VT with pulse (stable) and SVT: 150 mg
The longer the infusion of intravenous amiodarone, the greater the amount of parent and metabolite that is deposited in the deep compartment.
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Utdrag ur Läkemedelsverkets databas BiSi - PDF Free
Drug name Administration Dosing instruction How to titrate Monitoring/Other information Amiodarone (Cordarone ®150mg/3ml) 150mg/100mL 600-900 mg/500mL Max conc: 2mg/mL Solution: D5W only ACLS : 300 mg bolus then 150 mg over 10 min Infusion: 1 mg/min x 6 h then 0.5 mg/min x18 h Max dose 2.2 g/day Postoperatively, occurrences of adult respiratory distress syndrome reported in patients receiving amiodarone therapy who have undergone either cardiac or noncardiac surgery; although patients Amiodarone has been the first line treatment for certain forms of heart arrhythmia since it was first used in 1961. However, intravenous (IV) administration of the drug frequently leads to phlebitis, which is defined as an inflammation of the vein wall characterized by pain, edema, erythema, streak formation and/or a palpable cord.
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The drug prevents the recurrence of life-threatening ventricular arrhythmias and Amiodarone HCl is a white to slightly yellow crystalline powder, and is very slightly soluble in water. It has a molecular weight of 681.78 and contains 37.3% iodine by weight.